Peppermint oil
Peppermint oil as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury
Peppermint Oil and DILI
While peppermint oil is generally considered safe for most people when used in appropriate amounts, there have been rare cases of liver injury associated with its use. DILI is a condition where the liver is damaged as a result of exposure to certain medications, supplements, or toxins.
Some studies have suggested that high doses of peppermint oil may have hepatotoxic effects, meaning they could potentially harm the liver. It is believed that the menthol component in peppermint oil may be responsible for these effects.
Precautions
If you are considering using peppermint oil, especially in high doses or for an extended period of time, it is important to consult with a healthcare provider, particularly if you have a history of liver problems or are taking medications that may affect liver function.
It is also recommended to use high-quality peppermint oil from a reputable source and to follow the recommended dosage guidelines. If you experience any symptoms of liver injury, such as jaundice, abdominal pain, or dark urine, discontinue use of peppermint oil and seek medical attention immediately.
In conclusion, while peppermint oil is generally safe for most people when used appropriately, it is important to be aware of the potential risks of liver injury, especially in high doses. Consulting with a healthcare provider before using peppermint oil can help ensure its safe use.
Supplements for DILI
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
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Green tea extract
Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.
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Greater celandine
Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.
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Chaparral
Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.
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Germander
Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.
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Mistletoe
Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.
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Skullcap
Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.
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Valerian
Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.
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Kava kava
Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.
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St. John's wort
Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.
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Ginseng
Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.
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Aloe vera
Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.
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Ashwagandha
Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.
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Andrographis
Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.
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Noni juice
Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.
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Peppermint oil
Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.
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Kratom
Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.
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Ephedra
Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.
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